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Zalcitabine (Deuce'-Threesome'-dideoxydeoxycytidine, ddC), occurs as derivative of the naturally existent deoxycytidine, made by replacing the hydroxyl group in position Tierce' by owning the hydrogen. These are phosphorylated in the T cell into its active triphosphate form, ddCTP. This active metabolite works as a substrate for the reverse transcriptase, and too by incorporation into a viral DNA, hence terminating a chain elongation due to the missing hydroxyl group. Since zalcitabine occurs as reverse transcriptase inhibitor it possess activity only against retroviruses. These are utilized for the professional assistance of HIV infection only within combination by having zidovudine. Zalcitabine has the super high unwritten absorption rate, of ended Lxxx %. A usual side symptom in the beginning of the coarse of action is infection & headache. A supplementary good side results come peripheral neuropathy, oesophagitis and pancreatitis. Imputable its comparatively light potency, inconvenient dosing, & good side results, zalcitabine is no yearn ordinarily utilized to address HIV.
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Zalcitabine a.k.a. ddc, Hivid. DrugDigest: Zalcitabine Information on dosage, usage, side effects, interactions, and drug comparisons, including generics when available. Sold under brand names such as: Hivid, ddC, and dideoxycytidine. Hivid Full prescribing information from RxList. HIVID - Zalcitabine Roche USA Official HIVID site which contains a link to the package insert in PDF format. |
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